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How did I miss this thread for so long? Sounds like people have covered most of my usual recommendations already, but I'll give my input on them anyway.
SpiderOak is amazing (I'm pretty sure I did a write-up on using SpiderOak a few years ago that was my only published article on this very site). They're a little expensive, but I feel that's worth it for the zero-knowledge encryption guarantee and the reliability of their service. The only time I had problems with them was right after they ran a massive deal where you could get 1TB of storage for a very low yearly price indefinitely and they picked up way more new customers than expected. They had some stability issues due to overloading for a little while after that, but that has long since been resolved. I seriously cannot recommend them enough if you're willing to pay a bit more for a drop dead simple and reliable encrypted backup service.... if you haven't signed up already, do ping me so I can send you a referral link.... every person you refer gets you 1GB of free storage in perpetuity (at least I think they still do that).
OwnCloud - I wouldn't use OwnCloud. It has had issues in the past with losing data, plus the project just got forked and a bunch of the devs left. Otherwise, see NextCloud below.
NextCloud - This is the fork of OwnCloud that a bunch of the devs went to. If I were going to go with one of these two projects, I'd choose this one. I've read that the data loss issues have been resolved, but I've never been particularly fond of the way they do data syncing in the first place. The fact that it's all handled with PHP scripts and plain files on disk is a questionable design choice in my opinion, especially when you start running into PHP script timeout and memory issues. Own/NextCloud are great products when it comes to Calendar sync, Contact sync and things like that, but I wouldn't trust my important files to it when there are better options out there.
Seafile - This is the roll-your-own solution that I use for centralized file storage and sync. It's a bit more complicated to set up than the above two, but it runs as it's own daemon (that you then proxy through a standard webserver) and uses a git-like data storage format which both make it more resilient to data loss in my experience. It also has baked in encryption on a per sync folder level, so you can add a layer of security to your sensitive data, but not bother with that overhead on things that don't need it.
SyncThing - This one isn't so much a backup solution as it is just a file sync solution. I use it for certain backup tasks though. Operates like bittorrent sync, sort of. If you're going to run your own server you can easily use it to automatically back up certain folders any time something changes (and there are various options for keeping historical versions). Probably not what you're looking for, but worth mentioning anyway. I mostly use it to copy backups of certain application's data (like aCar) off of my phone automatically every night.
Duplicity, Deja-Dup, Duplicati - (Note: I haven't used Duplicati before, but have used the other two and it looks quite similar) - These are all great solutions for automating encrypted backups to not inherently secure locations such as Amazon S3. They use standard encryption (GPG) and do incremental backups to save on bandwidth and storage. Combine them with Glacier (if you don't think you'll have to restore files often, since it costs extra to retrieve data from Glacier) and you have a very cost effective encrypted, off-site backup system. In the past, I have done backups to a local NAS device, then had a Linux VM that would use duplicity to encrypt and ship to S3 for "cold storage". Probably the only solution that would meet your cost requirements.
CrashPlan - Used it in the past and do not like it. Their software was always bloated (ugh. Java) and unreliable for me. Plus you're relying on your friends keeping their storage up and running for you to back up to (or paying them for storage, and if you're doing that, IMO, you're better off going with SpiderOak). This thing was removed from my and my wife's computers in less than a few months because it was such a resource hog.
As anyone who is willing to listen to me knows, because I ramble on about it, I volunteer at a local animal shelter. They're raising money to renovate the (very dated) shelter and expand it. These people do a lot of good and find many animals furever homes each year, but they're frequently running out of space and the facilities really need updating. Every spare dollar helps, Icrontic. Earn some karma and help the fuzzbutts!
I've got a salute for the governor... but it might get me harassed by security.
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