RADA - Once fully installed, the motherboard is not as easily "accidentally" assessable as one might guess. My five year old has been hands off, and in fact, its been great to see her take an interest in whats going while knowing full well that Daddy says, keep your hand out of there. How many kids know what a processor heatsink does? (my kid) Your mileage may very, but I have zero reservations using the Skeleton around my five year old. If your kid can keep their finger out of a light socket, and resist the temptation to jab themselves in the eye with a fork, they should be able to handle it.

Pets, that's another problem entirely, one that I currently do not have. I could see where cats are possibly a deterrent to having this case. SPCA maybe? :*)

That 250mm fan moves alot of air, its impressive. Point being, after a few weeks of use, I believe the fan effectively agitates the air over the board well enough, that dust really has not built up. I would rate my home as as kinda dusty too. With the fan off, if dust settles and builds up, its easy to remove with a quick blast from a can of air. As I pointed out, I actually think this is a huge benefit. Look at a standard case design, dust is going to get through the intake somehow, even with good filters its not 100% avoidable. So what happens once its in, its trapped, and other than the most extreme enthusiasts, who opens their case often enough to notice the build up? Trust me, I have seen case innards that must be health code violations, that's how gross they were. With the Skeletons open design, dust does not get trapped, its easily inspected, and it actually helps you keep your system cleaner than any ordinary enclosure. I think this is a major pro of the design, and something that has been missed on allot of the reviews I have seen.