My question is - how do you interact with the game? Generally, to work a controller (mouse, keyboard, gamepad, etc), some sort of visual cue directs your replies, although many players react to audio cues - and some, such as me in my competetive quake days - are split possibly as much as 50/50 visual/aural responses.
However, to competely take away visuals would be rough, especially if you can't supplement directional reactivity with touch or scent.
I don't know if this could be done in space...I would think more of a city or forest setting might work better, as it could be filled with familiar sounds.
Perhaps the game has no setting - you might need to totally break out of the box of conceiving of a "place" and instead think in terms of a state of mind.
Also, any innovation is good innovation - even failures, should this be one (and I'm in no way saying it will be) help make things better in the long run (unless it's due to poor execution of a brilliant concept that makes everyone shy away from ever trying it again - please don't be an example of that
Keep me posted on what you come up with! And in the meantime, check out ReZ for the Dreamcast (import) and Playstation 2.