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Search assistant & co. + Mprexe

Hallo!
I'm a new user and I registred because here I saw many people with my problems.
Excuse me in advance for my english, I'm Italian.

I've problems on two computers:

- The first one is the one I'm using now, a laptop (or notebook...) with Win98; it had the problems of "Search assistant uninstall" between the installed programs, about:blank/search as homepage, many popups and some blocked sites.
I ran HijackThis and now it's almost clear: it remains the problems of the many popups that say i'm infected by spyware...
Do I have to run Adaware SE Personal and Spybot Search & Destroy 1.3, then HijackThis again and then post my log ?
Or there are other solutions?

-The second computer is a pc using WinME: it has "Search assistant uninstall", "Search extender", "Home search assistent" and "Shopping wizard help"... and maybe some other things that I don't know! It has the same problems (changed homepage, popups and some blocked sites) but just HijackThis doesn't work and there is another problem!
At system start up there's a notice of an error: "Mprexe caused an error in Kernel32.dll" and many times the system doesn't finish the startup and blocks before seeing the desktop.
I searched about this error and on Microsoft site it says that it's about lack of ram, but I don't think it's my problem... I think it could be related to all this spyware. What do you think about it?

Can you help me please?
Thank you in advance!

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