Disclaimer: I work for AMD.The AMD Radeon HD 6800 and 6900 Series cards support six simultaneous displays at resolutions up to 2560x1600. This requires monitors, splitters or hubs that support DisplayPort 1.2 Multi-Stream Transport. Using this technology, you can run 3 displays per Mini DisplayPort port on these cards. MST-enabled hubs or displays are pretty rare (and expensive) until the spring, but I wanted to point out that the multi-monitor capabilities of these cards is going to improve again in the spring.Without using hubs or splitters, you can get four simultaneous displays working on these cards. You can connect two 1920x1200 monitors via DVI, and any monitor beyond that has to be connected to one of the two Mini DisplayPort jacks on the card. If your monitors aren't mDP, these cheap adapters will do the trick.If you would rather use three 2560x1600 displays, connect two displays via mDP, and connect the third to the top DVI port.At this time, NVIDIA cannot support more than three simultaneous displays, and you must buy two GPUs to do it.//EDIT: For your needs, I recommend the Radeon HD 6850.