Best Of
Re: Deepmind and what it means for the future of folding
Deepmind is a powerful (most powerful?) AI but it is still only entity. Science is obsessed with reproducing results until they can get to 5 sigma (99.999%). In the near term, F@H can help reach that level by targeting the proteins that Deepmind had solved. In the long term, with Deepmind cracking the "code", I hope it will lead to huge leap in more efficient and powerful algorithms on protein folding. Then Stanford and F@H can piggyback on that knowledge and unleash a new wave in Folding that sees the project knock out entire sequences of proteins in a few dozen months instead of dozens of years. I mean, almost 2 million GPU and CPU cores currently working with F@H, we are still a powerhouse.
QCH
Re: F@h-La-La-La-La
Other than my primary desktop, I moved folding rigs into the server room at work, so they're nice and cool. When everything is cranking I can usually do ~5M PPD.
mas0n
Re: Killa.Cliff's Colossal Calamity
So I did a thing tonight. I used the Steam "delete this game from my library" feature on the support site to get rid of a good 120 games that I absolutely have no intent of playing or touching ever again. I still have too many, but now I can browse my library and actually make some reasonably educated decisions on a few things I might like to actually try, or go back and finish. I know it's the cowards way out, but it had to be done.
Re: F@h-La-La-La-La
New AMD GPU f@h data is up https://folding.lar.systems/folding_data/gpu_ppd_overall . Not to bad 
_k
Re: IC Secret Santa
I already got my gift from my Secret Santa! @Kwitko is on top of it. Thank you so much, Seth! 🥰🤗
(Essential oil diffuser and LOTS of dark chocolate)
WagsFTW
Re: ReactOS
It's more realistic today, in that it could be accomplished at a technical level, but still terribly unlikely to happen.
Big names that are only part-time insane, like Eric S. Raymond, have been wondering aloud about this.
So, you’re a Microsoft corporate strategist. What’s the profit-maximizing path forward given all these factors?
It’s this: Microsoft Windows becomes a Proton-like emulation layer over a Linux kernel, with the layer getting thinner over time as more of the support lands in the mainline kernel sources. The economic motive is that Microsoft sheds an ever-larger fraction of its development costs as less and less has to be done in-house.
It's fun to think about, but plenty of people have dismantled his argument over the last two months. It is interesting that today, Microsoft "❤" Linux, Edge is available on Linux, and the full-fat actual Linux kernel is delivered by Microsoft as WSL via the Microsoft Store.
I don't think Windows will be open source any time soon. It'll stay pretty much the way it is so they can keep extracting money out of legacy clients and data out of end users. But I wouldn't have predicted Microsoft's embrace (ahem) of Linux back in 2007.
Garg